I have thought about it for a while. I am a fan of Rocky Horror. I am also a huge fan of Family Guy. So of course I wonder what it might be like if Family Guy finally did a recreation of the cult classic. I have put together a cast list of what I have in mind.
Rocky Family Horror Guy Picture Show
Dr. Frank-N-Furter - A Scientist = Stewie Griffin
Janet Weiss - A Heroine = Bonnie Swanson
Brad Majors - A Hero = Glen Quagmire
Riff Raff - A Handyman = Chris Griffin
Magenta - A Domestic = Meg Griffin
Columbia - A Groupie = Lois Griffin
Dr. Everett V. Scott - A Rival Scientist = Joe Swanson
Rocky Horror - A Creation = Brian Griffin
Eddie - Ex Delivery Boy = Peter Griffin
The Criminologist - An Expert = Adam West
The Transylvanians = Various citizens of Quahog
Personally I don't think this will ever happen, at least not for release on TV, But one can dream!